Drug interactions
Cocaine + Isoniazid
Severity: Minor
Cocaine and Isoniazid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cocaine blocks serotonin reuptake and isoniazid has weak MAO inhibiting activity, so serotonergic toxicity is theoretically possible. With topical clinical use, systemic cocaine exposure is small and the risk is low. Illicit systemic use carries more concern, including hypertensive reactions.
What this interaction means in plain words
Cocaine and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cocaine belongs to Central Nervous System; Isoniazid belongs to Anti Bacterial.
Why it happens
Monoamine reuptake inhibition by cocaine combined with weak MAO inhibition by isoniazid.
What to do
With topical use no action is needed beyond awareness. Monitor for agitation, hypertension, and hyperthermia if systemic exposure occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Isoniazid
Other interactions of Cocaine
- Cocaine + Isocarboxazid Contraindicated
- Cocaine + Phenelzine Contraindicated
- Cocaine + Procarbazine Contraindicated
- Amitriptyline + Cocaine Major
- Bisoprolol + Cocaine Major
- Citalopram + Cocaine Major
Frequently asked questions
Can I take Cocaine with Isoniazid?
MediHelp rates the interaction as minor. Cocaine and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cocaine blocks serotonin reuptake and isoniazid has weak MAO inhibiting activity, so serotonergic toxicity is theoretically possible. With topical clinical use, systemic cocaine exposure is small and the risk is low. Illicit systemic use carries more concern, including hypertensive reactions.
How serious is the interaction between Cocaine and Isoniazid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: With topical use no action is needed beyond awareness. Monitor for agitation, hypertension, and hyperthermia if systemic exposure occurs.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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