Drug interactions
Codeine + Dextroamphetamine
Severity: Minor
Codeine and Dextroamphetamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stimulants may offset some opioid sedation but do not reverse respiratory depression, and the net effect is unpredictable. Amphetamines can also increase the potentiating effects of opioid analgesia in some settings.
What this interaction means in plain words
Codeine and Dextroamphetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Codeine belongs to Musculoskeletal; Dextroamphetamine belongs to Central Nervous System.
Why it happens
Opposing CNS effects; no firmly established pharmacokinetic mechanism.
What to do
No routine adjustment is needed; monitor for unexpected changes in sedation, blood pressure and heart rate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Codeine
- Alvimopan + Codeine Contraindicated
- Codeine + Isocarboxazid Contraindicated
- Codeine + Olanzapine / samidorphan Contraindicated
- Codeine + Phenelzine Contraindicated
- Codeine + Tranylcypromine Contraindicated
- Alfentanil + Codeine Major
Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Codeine with Dextroamphetamine?
MediHelp rates the interaction as minor. Codeine and Dextroamphetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Stimulants may offset some opioid sedation but do not reverse respiratory depression, and the net effect is unpredictable. Amphetamines can also increase the potentiating effects of opioid analgesia in some settings.
How serious is the interaction between Codeine and Dextroamphetamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for unexpected changes in sedation, blood pressure and heart rate.
What other medicines interact with Codeine?
MediHelp also lists interactions of Codeine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Codeine page.
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