Drug interactions
Codeine + Diethylpropion
Severity: Minor
Codeine and Diethylpropion: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diethylpropion is a stimulant anorectic that may partly offset opioid drowsiness, but it does not reverse opioid respiratory depression. The net effect is unpredictable and stimulant effects may mask sedation.
What this interaction means in plain words
Codeine and Diethylpropion have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing pharmacodynamic CNS effects; no established pharmacokinetic interaction.
What to do
No dose change is routinely needed; monitor alertness and respiratory status after starting codeine and do not rely on the stimulant to counter opioid effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Codeine
- Alvimopan + Codeine Contraindicated
- Codeine + Isocarboxazid Contraindicated
- Codeine + Olanzapine / samidorphan Contraindicated
- Codeine + Phenelzine Contraindicated
- Codeine + Tranylcypromine Contraindicated
- Alfentanil + Codeine Major
Frequently asked questions
Can I take Codeine with Diethylpropion?
MediHelp rates the interaction as minor. Codeine and Diethylpropion have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Diethylpropion is a stimulant anorectic that may partly offset opioid drowsiness, but it does not reverse opioid respiratory depression. The net effect is unpredictable and stimulant effects may mask sedation.
How serious is the interaction between Codeine and Diethylpropion?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely needed; monitor alertness and respiratory status after starting codeine and do not rely on the stimulant to counter opioid effects.
What other medicines interact with Codeine?
MediHelp also lists interactions of Codeine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Codeine page.
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