Drug interactions
Codeine + Epinephrine racemic
Severity: Minor
Codeine and Epinephrine racemic: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Racemic epinephrine, usually given by inhalation, has no meaningful sedative effect and no established interaction with codeine. Any opposing stimulant effect is minimal and unreliable.
What this interaction means in plain words
Codeine and Epinephrine racemic have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
No established mechanism; theoretical opposing pharmacodynamic effects only.
What to do
No specific action is required; continue routine monitoring of sedation and respiratory status.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Codeine
- Alvimopan + Codeine Contraindicated
- Codeine + Isocarboxazid Contraindicated
- Codeine + Olanzapine / samidorphan Contraindicated
- Codeine + Phenelzine Contraindicated
- Codeine + Tranylcypromine Contraindicated
- Alfentanil + Codeine Major
Frequently asked questions
Can I take Codeine with Epinephrine racemic?
MediHelp rates the interaction as minor. Codeine and Epinephrine racemic have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Racemic epinephrine, usually given by inhalation, has no meaningful sedative effect and no established interaction with codeine. Any opposing stimulant effect is minimal and unreliable.
How serious is the interaction between Codeine and Epinephrine racemic?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is required; continue routine monitoring of sedation and respiratory status.
What other medicines interact with Codeine?
MediHelp also lists interactions of Codeine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Codeine page.
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