Drug interactions
Codeine + Loxapine inhaled
Severity: Moderate
Codeine and Loxapine inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Inhaled loxapine can cause sedation and bronchospasm, and combining it with opioids adds to central nervous system depression. Respiratory effects may be more pronounced in vulnerable patients.
What this interaction means in plain words
Codeine and Loxapine inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects of an antipsychotic and an opioid.
What to do
Monitor sedation and respiratory status, particularly after the loxapine dose. Reduce the opioid dose if excessive drowsiness occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Codeine
- Alvimopan + Codeine Contraindicated
- Codeine + Isocarboxazid Contraindicated
- Codeine + Olanzapine / samidorphan Contraindicated
- Codeine + Phenelzine Contraindicated
- Codeine + Tranylcypromine Contraindicated
- Alfentanil + Codeine Major
Frequently asked questions
Can I take Codeine with Loxapine inhaled?
MediHelp rates the interaction as moderate. Codeine and Loxapine inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Inhaled loxapine can cause sedation and bronchospasm, and combining it with opioids adds to central nervous system depression. Respiratory effects may be more pronounced in vulnerable patients.
How serious is the interaction between Codeine and Loxapine inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory status, particularly after the loxapine dose. Reduce the opioid dose if excessive drowsiness occurs.
What other medicines interact with Codeine?
MediHelp also lists interactions of Codeine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Codeine page.
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