Drug interactions
Codeine + Quinacrine
Severity: Minor
Codeine and Quinacrine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinacrine may inhibit CYP2D6, which could reduce conversion of codeine to morphine and weaken analgesia. Data are sparse and the effect is mainly predicted.
What this interaction means in plain words
Codeine and Quinacrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible inhibition of CYP2D6-mediated O-demethylation of codeine to morphine.
What to do
Monitor pain control and consider a non-CYP2D6-dependent analgesic if codeine response is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Codeine
- Alvimopan + Codeine Contraindicated
- Codeine + Isocarboxazid Contraindicated
- Codeine + Olanzapine / samidorphan Contraindicated
- Codeine + Phenelzine Contraindicated
- Codeine + Tranylcypromine Contraindicated
- Alfentanil + Codeine Major
Frequently asked questions
Can I take Codeine with Quinacrine?
MediHelp rates the interaction as minor. Codeine and Quinacrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Quinacrine may inhibit CYP2D6, which could reduce conversion of codeine to morphine and weaken analgesia. Data are sparse and the effect is mainly predicted.
How serious is the interaction between Codeine and Quinacrine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor pain control and consider a non-CYP2D6-dependent analgesic if codeine response is inadequate.
What other medicines interact with Codeine?
MediHelp also lists interactions of Codeine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Codeine page.
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