Drug interactions
Codeine + Topiramate
Severity: Moderate
Codeine and Topiramate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Topiramate can cause drowsiness and cognitive slowing, which add to the sedative effect of codeine. The combination may impair alertness and psychomotor performance.
What this interaction means in plain words
Codeine and Topiramate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Codeine belongs to Musculoskeletal; Topiramate belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Start with low doses and monitor for sedation and respiratory depression. Advise patients to avoid driving and alcohol until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Codeine
- Alvimopan + Codeine Contraindicated
- Codeine + Isocarboxazid Contraindicated
- Codeine + Olanzapine / samidorphan Contraindicated
- Codeine + Phenelzine Contraindicated
- Codeine + Tranylcypromine Contraindicated
- Alfentanil + Codeine Major
Other interactions of Topiramate
Frequently asked questions
Can I take Codeine with Topiramate?
MediHelp rates the interaction as moderate. Codeine and Topiramate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Topiramate can cause drowsiness and cognitive slowing, which add to the sedative effect of codeine. The combination may impair alertness and psychomotor performance.
How serious is the interaction between Codeine and Topiramate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with low doses and monitor for sedation and respiratory depression. Advise patients to avoid driving and alcohol until the response is known.
What other medicines interact with Codeine?
MediHelp also lists interactions of Codeine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Codeine page.
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