Drug interactions
Collagenase clostridium histolyticum + Dabigatran etexilate
Severity: Moderate
Collagenase clostridium histolyticum and Dabigatran etexilate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Collagenase injection commonly causes bruising and hematoma at the injection site, which may be increased in patients on anticoagulants.
What this interaction means in plain words
Collagenase clostridium histolyticum and Dabigatran etexilate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Anticoagulation by dabigatran adds to local tissue bleeding from collagenase-induced tissue disruption.
What to do
Review the need for treatment while on anticoagulants and consider delaying elective injection. Monitor the injection site for hematoma.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dabigatran etexilate
- Dabigatran etexilate + Defibrotide Contraindicated
- Dabigatran etexilate + Ketorolac Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
- Abciximab + Dabigatran etexilate Major
- Alteplase + Dabigatran etexilate Major
- Amiodarone + Dabigatran etexilate Major
Frequently asked questions
Can I take Collagenase clostridium histolyticum with Dabigatran etexilate?
MediHelp rates the interaction as moderate. Collagenase clostridium histolyticum and Dabigatran etexilate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Collagenase injection commonly causes bruising and hematoma at the injection site, which may be increased in patients on anticoagulants.
How serious is the interaction between Collagenase clostridium histolyticum and Dabigatran etexilate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review the need for treatment while on anticoagulants and consider delaying elective injection. Monitor the injection site for hematoma.
What other medicines interact with Dabigatran etexilate?
MediHelp also lists interactions of Dabigatran etexilate with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dabigatran etexilate page.
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