Drug interactions
Collagenase clostridium histolyticum + Enoxaparin
Severity: Moderate
Collagenase clostridium histolyticum and Enoxaparin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Collagenase injections frequently cause bruising and hematoma at the injection site, and anticoagulation may worsen this. Labeling advises caution with anticoagulants other than low-dose aspirin.
What this interaction means in plain words
Collagenase clostridium histolyticum and Enoxaparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Local tissue disruption by collagenase combined with impaired coagulation from enoxaparin increases bleeding and hematoma.
What to do
Where feasible, time the injections when anticoagulation can be held, or weigh benefit against risk. Monitor the injection site for hematoma or excessive bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Collagenase clostridium histolyticum and Enoxaparin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Enoxaparin
- Defibrotide + Enoxaparin Contraindicated
- Enoxaparin + Ketorolac Contraindicated
- Enoxaparin + Mifepristone Contraindicated
- Abciximab + Enoxaparin Major
- Aceclofenac + Enoxaparin Major
- Acetylsalicylic acid + Enoxaparin Major
Frequently asked questions
Can I take Collagenase clostridium histolyticum with Enoxaparin?
MediHelp rates the interaction as moderate. Collagenase clostridium histolyticum and Enoxaparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Collagenase injections frequently cause bruising and hematoma at the injection site, and anticoagulation may worsen this. Labeling advises caution with anticoagulants other than low-dose aspirin.
How serious is the interaction between Collagenase clostridium histolyticum and Enoxaparin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where feasible, time the injections when anticoagulation can be held, or weigh benefit against risk. Monitor the injection site for hematoma or excessive bleeding.
What other medicines interact with Enoxaparin?
MediHelp also lists interactions of Enoxaparin with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Enoxaparin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
