Drug interactions
Conivaptan + Cyclosporin
Severity: Major
Conivaptan and Cyclosporin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Conivaptan is a CYP3A4 substrate and inhibitor, and cyclosporine inhibits CYP3A4, so both drugs can reach higher concentrations. This may increase cyclosporine toxicity and cause excessively rapid sodium correction with conivaptan.
What this interaction means in plain words
Conivaptan and Cyclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Mutual inhibition of CYP3A4-mediated metabolism.
What to do
Monitor cyclosporine levels and renal function, and check serum sodium frequently to avoid overly rapid correction. Reduce doses if needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Conivaptan with Cyclosporin?
MediHelp rates the interaction as major. Conivaptan and Cyclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Conivaptan is a CYP3A4 substrate and inhibitor, and cyclosporine inhibits CYP3A4, so both drugs can reach higher concentrations. This may increase cyclosporine toxicity and cause excessively rapid sodium correction with conivaptan.
How serious is the interaction between Conivaptan and Cyclosporin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine levels and renal function, and check serum sodium frequently to avoid overly rapid correction. Reduce doses if needed.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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