Drug interactions
Conivaptan + Erlotinib
Severity: Moderate
Conivaptan and Erlotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Conivaptan is a CYP3A4 inhibitor that may raise erlotinib concentrations. Higher exposure may increase rash, diarrhea and other adverse effects of erlotinib.
What this interaction means in plain words
Conivaptan and Erlotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4 reduces erlotinib metabolism.
What to do
Monitor for erlotinib toxicity such as severe diarrhea and rash during the short conivaptan course. Reduce the erlotinib dose if severe reactions develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erlotinib
- Amobarbital + Erlotinib Major
- Apalutamide + Erlotinib Major
- Carbamazepine + Erlotinib Major
- Cobicistat + Erlotinib Major
- Darunavir + Erlotinib Major
- Dexlansoprazole + Erlotinib Major
Frequently asked questions
Can I take Conivaptan with Erlotinib?
MediHelp rates the interaction as moderate. Conivaptan and Erlotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Conivaptan is a CYP3A4 inhibitor that may raise erlotinib concentrations. Higher exposure may increase rash, diarrhea and other adverse effects of erlotinib.
How serious is the interaction between Conivaptan and Erlotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for erlotinib toxicity such as severe diarrhea and rash during the short conivaptan course. Reduce the erlotinib dose if severe reactions develop.
What other medicines interact with Erlotinib?
MediHelp also lists interactions of Erlotinib with, for example, Amobarbital, Apalutamide, Carbamazepine. The full list is on the Erlotinib page.
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