Drug interactions
Conivaptan + Fluticasone-salmeterol
Severity: Moderate
Conivaptan and Fluticasone-salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Conivaptan is a CYP3A4 inhibitor, and both salmeterol and fluticasone are CYP3A4 substrates. Higher salmeterol exposure can increase cardiovascular effects such as tachycardia and QT prolongation, and higher fluticasone exposure can cause systemic corticosteroid effects. Conivaptan is given only for short courses, which limits the duration of the risk.
What this interaction means in plain words
Conivaptan and Fluticasone-salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated metabolism of salmeterol and fluticasone by conivaptan.
What to do
Monitor heart rate, ECG and potassium during conivaptan therapy. Watch for signs of corticosteroid excess if combined for longer than a short period.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Frequently asked questions
Can I take Conivaptan with Fluticasone-salmeterol?
MediHelp rates the interaction as moderate. Conivaptan and Fluticasone-salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Conivaptan is a CYP3A4 inhibitor, and both salmeterol and fluticasone are CYP3A4 substrates. Higher salmeterol exposure can increase cardiovascular effects such as tachycardia and QT prolongation, and higher fluticasone exposure can cause systemic corticosteroid effects. Conivaptan is given only for short courses, which limits the duration of the risk.
How serious is the interaction between Conivaptan and Fluticasone-salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, ECG and potassium during conivaptan therapy. Watch for signs of corticosteroid excess if combined for longer than a short period.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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