Drug interactions
Conivaptan + Ifosfamide
Severity: Moderate
Conivaptan and Ifosfamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Conivaptan is a CYP3A4 inhibitor that may reduce conversion of ifosfamide to its active alkylating metabolites, potentially lowering efficacy. Inhibition of CYP3A4 would also alter formation of chloroacetaldehyde. The inhibitory effect persists for some days after conivaptan stops.
What this interaction means in plain words
Conivaptan and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Conivaptan inhibits CYP3A4, the enzyme involved in ifosfamide bioactivation and dechloroethylation.
What to do
Avoid overlap where an alternative treatment for hyponatremia is available. If used together, monitor for reduced antitumour response and for neurologic and renal toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Frequently asked questions
Can I take Conivaptan with Ifosfamide?
MediHelp rates the interaction as moderate. Conivaptan and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Conivaptan is a CYP3A4 inhibitor that may reduce conversion of ifosfamide to its active alkylating metabolites, potentially lowering efficacy. Inhibition of CYP3A4 would also alter formation of chloroacetaldehyde. The inhibitory effect persists for some days after conivaptan stops.
How serious is the interaction between Conivaptan and Ifosfamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid overlap where an alternative treatment for hyponatremia is available. If used together, monitor for reduced antitumour response and for neurologic and renal toxicity.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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