Drug interactions
Conivaptan + Imipramine
Severity: Moderate
Conivaptan and Imipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Conivaptan is a CYP3A4 inhibitor and may increase imipramine exposure. This could add to anticholinergic, sedative and cardiac adverse effects of the tricyclic, although the clinical effect is probably modest because CYP3A4 is a secondary route.
What this interaction means in plain words
Conivaptan and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated imipramine metabolism.
What to do
Monitor for signs of TCA toxicity, such as sedation, tachycardia and conduction changes, during the short conivaptan course. Reduce the imipramine dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Conivaptan with Imipramine?
MediHelp rates the interaction as moderate. Conivaptan and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Conivaptan is a CYP3A4 inhibitor and may increase imipramine exposure. This could add to anticholinergic, sedative and cardiac adverse effects of the tricyclic, although the clinical effect is probably modest because CYP3A4 is a secondary route.
How serious is the interaction between Conivaptan and Imipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of TCA toxicity, such as sedation, tachycardia and conduction changes, during the short conivaptan course. Reduce the imipramine dose if adverse effects occur.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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