Drug interactions
Conivaptan + Isosorbide dinitrate
Severity: Minor
Conivaptan and Isosorbide dinitrate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Conivaptan is a CYP3A4 inhibitor, but isosorbide dinitrate is cleared mainly by hepatic denitration and not mainly by CYP3A4. A clinically significant increase in nitrate exposure is unlikely.
What this interaction means in plain words
Conivaptan and Isosorbide dinitrate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Conivaptan inhibits CYP3A4, a minor pathway for dinitrate.
What to do
No dose change is needed. Monitor blood pressure during the conivaptan infusion.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Isosorbide dinitrate
- Avanafil + Isosorbide dinitrate Contraindicated
- Isosorbide dinitrate + Riociguat Contraindicated
- Isosorbide dinitrate + Sildenafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Ergotamine + Isosorbide dinitrate Major
Frequently asked questions
Can I take Conivaptan with Isosorbide dinitrate?
MediHelp rates the interaction as minor. Conivaptan and Isosorbide dinitrate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Conivaptan is a CYP3A4 inhibitor, but isosorbide dinitrate is cleared mainly by hepatic denitration and not mainly by CYP3A4. A clinically significant increase in nitrate exposure is unlikely.
How serious is the interaction between Conivaptan and Isosorbide dinitrate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Monitor blood pressure during the conivaptan infusion.
What other medicines interact with Isosorbide dinitrate?
MediHelp also lists interactions of Isosorbide dinitrate with, for example, Avanafil, Riociguat, Sildenafil. The full list is on the Isosorbide dinitrate page.
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