Drug interactions
Conivaptan + Nifedipine
Severity: Minor
Conivaptan and Nifedipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Conivaptan is metabolized by CYP3A4 and is itself a CYP3A4 inhibitor; nifedipine is a weak CYP3A4 substrate with little inhibitory effect, so a clinically meaningful rise in conivaptan is unlikely. Conivaptan may raise nifedipine levels, with possible hypotension.
What this interaction means in plain words
Conivaptan and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Conivaptan inhibits CYP3A4, which may modestly increase nifedipine exposure.
What to do
Monitor blood pressure during conivaptan infusion in patients taking nifedipine. Adjust the nifedipine dose if hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nifedipine
Frequently asked questions
Can I take Conivaptan with Nifedipine?
MediHelp rates the interaction as minor. Conivaptan and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Conivaptan is metabolized by CYP3A4 and is itself a CYP3A4 inhibitor; nifedipine is a weak CYP3A4 substrate with little inhibitory effect, so a clinically meaningful rise in conivaptan is unlikely. Conivaptan may raise nifedipine levels, with possible hypotension.
How serious is the interaction between Conivaptan and Nifedipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during conivaptan infusion in patients taking nifedipine. Adjust the nifedipine dose if hypotension occurs.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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