Drug interactions
Conivaptan + Nilotinib
Severity: Major
Conivaptan and Nilotinib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Conivaptan is a strong CYP3A4 inhibitor and can raise nilotinib concentrations, increasing the risk of QT prolongation and torsades de pointes.
What this interaction means in plain words
Conivaptan and Nilotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Inhibition of CYP3A4-mediated nilotinib metabolism by conivaptan.
What to do
Avoid if possible. Because conivaptan is a short-term infusion, consider holding nilotinib, or monitor ECG and electrolytes closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Conivaptan with Nilotinib?
MediHelp rates the interaction as major. Conivaptan and Nilotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Conivaptan is a strong CYP3A4 inhibitor and can raise nilotinib concentrations, increasing the risk of QT prolongation and torsades de pointes.
How serious is the interaction between Conivaptan and Nilotinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. Because conivaptan is a short-term infusion, consider holding nilotinib, or monitor ECG and electrolytes closely.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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