Drug interactions
Conivaptan + Quinine
Severity: Moderate
Conivaptan and Quinine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Conivaptan inhibits CYP3A4 and may increase quinine exposure, raising the risk of cinchonism and QT prolongation. The effect is predicted from the mechanism.
What this interaction means in plain words
Conivaptan and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition by conivaptan reducing quinine clearance.
What to do
Monitor ECG and for quinine toxicity during the short conivaptan course. Reduce quinine dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Frequently asked questions
Can I take Conivaptan with Quinine?
MediHelp rates the interaction as moderate. Conivaptan and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Conivaptan inhibits CYP3A4 and may increase quinine exposure, raising the risk of cinchonism and QT prolongation. The effect is predicted from the mechanism.
How serious is the interaction between Conivaptan and Quinine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and for quinine toxicity during the short conivaptan course. Reduce quinine dose if adverse effects occur.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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