Drug interactions
Conivaptan + Repaglinide
Severity: Moderate
Conivaptan and Repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Conivaptan is a CYP3A4 inhibitor and may raise repaglinide levels. This can enhance its glucose-lowering effect and cause hypoglycemia.
What this interaction means in plain words
Conivaptan and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Conivaptan inhibits CYP3A4, decreasing repaglinide metabolism.
What to do
Monitor blood glucose during the short conivaptan infusion course and for a few days afterward. Reduce the repaglinide dose or hold it if glucose is low.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporin + Repaglinide Major
- Deferasirox + Repaglinide Major
Frequently asked questions
Can I take Conivaptan with Repaglinide?
MediHelp rates the interaction as moderate. Conivaptan and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Conivaptan is a CYP3A4 inhibitor and may raise repaglinide levels. This can enhance its glucose-lowering effect and cause hypoglycemia.
How serious is the interaction between Conivaptan and Repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during the short conivaptan infusion course and for a few days afterward. Reduce the repaglinide dose or hold it if glucose is low.
What other medicines interact with Repaglinide?
MediHelp also lists interactions of Repaglinide with, for example, Gemfibrozil, Clarithromycin, Clopidogrel. The full list is on the Repaglinide page.
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