Drug interactions
Conivaptan + Salmeterol
Severity: Moderate
Conivaptan and Salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Conivaptan is a CYP3A4 inhibitor and can increase systemic exposure to salmeterol, which is a CYP3A4 substrate. Higher salmeterol levels may cause tachycardia, QT prolongation, tremor and hypokalemia.
What this interaction means in plain words
Conivaptan and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated metabolism of salmeterol by conivaptan.
What to do
Monitor heart rate, ECG and serum potassium during concurrent use, and watch for beta-agonist adverse effects. Conivaptan is given only for a short course, so reassess once it ends.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Frequently asked questions
Can I take Conivaptan with Salmeterol?
MediHelp rates the interaction as moderate. Conivaptan and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Conivaptan is a CYP3A4 inhibitor and can increase systemic exposure to salmeterol, which is a CYP3A4 substrate. Higher salmeterol levels may cause tachycardia, QT prolongation, tremor and hypokalemia.
How serious is the interaction between Conivaptan and Salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, ECG and serum potassium during concurrent use, and watch for beta-agonist adverse effects. Conivaptan is given only for a short course, so reassess once it ends.
What other medicines interact with Salmeterol?
MediHelp also lists interactions of Salmeterol with, for example, Ritonavir, Saquinavir, Amitriptyline. The full list is on the Salmeterol page.
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