Drug interactions
Conivaptan + Sofosbuvir-velpatasvir
Severity: Minor
Conivaptan and Sofosbuvir-velpatasvir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Conivaptan is a strong CYP3A4 inhibitor and may increase velpatasvir exposure. Velpatasvir has a wide safety margin, so the increase is unlikely to cause harm. Clinical significance is low.
What this interaction means in plain words
Conivaptan and Sofosbuvir-velpatasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Conivaptan inhibits CYP3A4, which is one of several pathways metabolizing velpatasvir.
What to do
No dose adjustment is required. Monitor for general adverse effects such as headache or fatigue.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sofosbuvir-velpatasvir
- Rifampin + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Sofosbuvir-velpatasvir + St john's wort Contraindicated
- Amiodarone + Sofosbuvir-velpatasvir Major
- Apalutamide + Sofosbuvir-velpatasvir Major
- Carbamazepine + Sofosbuvir-velpatasvir Major
Frequently asked questions
Can I take Conivaptan with Sofosbuvir-velpatasvir?
MediHelp rates the interaction as minor. Conivaptan and Sofosbuvir-velpatasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Conivaptan is a strong CYP3A4 inhibitor and may increase velpatasvir exposure. Velpatasvir has a wide safety margin, so the increase is unlikely to cause harm. Clinical significance is low.
How serious is the interaction between Conivaptan and Sofosbuvir-velpatasvir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required. Monitor for general adverse effects such as headache or fatigue.
What other medicines interact with Sofosbuvir-velpatasvir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir with, for example, Rifampin, Rifapentine, St john's wort. The full list is on the Sofosbuvir-velpatasvir page.
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