Drug interactions
Conivaptan + Sunitinib
Severity: Moderate
Conivaptan and Sunitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Conivaptan is a CYP3A4 inhibitor and may increase sunitinib exposure. Higher levels could increase toxicity such as hypertension, myelosuppression and QT prolongation, though conivaptan is used only short term.
What this interaction means in plain words
Conivaptan and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated sunitinib metabolism by conivaptan.
What to do
Monitor for sunitinib adverse effects during conivaptan infusion, including blood pressure and ECG. Consider a temporary sunitinib dose reduction or interruption if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Frequently asked questions
Can I take Conivaptan with Sunitinib?
MediHelp rates the interaction as moderate. Conivaptan and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Conivaptan is a CYP3A4 inhibitor and may increase sunitinib exposure. Higher levels could increase toxicity such as hypertension, myelosuppression and QT prolongation, though conivaptan is used only short term.
How serious is the interaction between Conivaptan and Sunitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sunitinib adverse effects during conivaptan infusion, including blood pressure and ECG. Consider a temporary sunitinib dose reduction or interruption if toxicity occurs.
What other medicines interact with Sunitinib?
MediHelp also lists interactions of Sunitinib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sunitinib page.
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