Drug interactions
Conjugated estrogens + Cyclosporin
Severity: Moderate
Conjugated estrogens and Cyclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine may increase estrogen exposure by inhibiting CYP3A4, P-glycoprotein and organic anion transporters. Estrogens may also alter cyclosporine levels, so each drug can affect the other. Increased estrogenic effects and fluctuations in cyclosporine levels are possible.
What this interaction means in plain words
Conjugated estrogens and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cyclosporine inhibits CYP3A4, P-gp and OATP transporters, reducing estrogen clearance.
What to do
Monitor for estrogen adverse effects such as hypertension and fluid retention, and check cyclosporine trough levels when estrogen therapy is started or changed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Conjugated estrogens with Cyclosporin?
MediHelp rates the interaction as moderate. Conjugated estrogens and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine may increase estrogen exposure by inhibiting CYP3A4, P-glycoprotein and organic anion transporters. Estrogens may also alter cyclosporine levels, so each drug can affect the other. Increased estrogenic effects and fluctuations in cyclosporine levels are possible.
How serious is the interaction between Conjugated estrogens and Cyclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for estrogen adverse effects such as hypertension and fluid retention, and check cyclosporine trough levels when estrogen therapy is started or changed.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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