Drug interactions
Conjugated estrogens vaginal + Cyclosporin
Severity: Minor
Conjugated estrogens vaginal and Cyclosporin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine could increase systemic estrogen exposure from vaginal conjugated estrogens. Systemic absorption from vaginal use is low, so the clinical effect is likely small.
What this interaction means in plain words
Conjugated estrogens vaginal and Cyclosporin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Cyclosporine inhibits CYP3A4 and P-glycoprotein, potentially reducing estrogen metabolism and efflux.
What to do
No routine action is needed beyond awareness. Monitor for systemic estrogen effects if high doses are used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Conjugated estrogens vaginal with Cyclosporin?
MediHelp rates the interaction as minor. Conjugated estrogens vaginal and Cyclosporin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cyclosporine could increase systemic estrogen exposure from vaginal conjugated estrogens. Systemic absorption from vaginal use is low, so the clinical effect is likely small.
How serious is the interaction between Conjugated estrogens vaginal and Cyclosporin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed beyond awareness. Monitor for systemic estrogen effects if high doses are used.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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