Drug interactions
Contrast media + Cyclosporin
Severity: Moderate
Contrast media and Cyclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iodinated contrast can cause acute kidney injury, and cyclosporine's renal vasoconstriction increases the vulnerability of the kidney. The combination can lead to a greater rise in serum creatinine.
What this interaction means in plain words
Contrast media and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxicity from cyclosporine afferent vasoconstriction and contrast-induced tubular injury and ischemia.
What to do
Ensure adequate hydration, use the lowest effective dose of contrast, and monitor serum creatinine and cyclosporine levels for several days afterward. Consider holding other nephrotoxic drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Contrast media with Cyclosporin?
MediHelp rates the interaction as moderate. Contrast media and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iodinated contrast can cause acute kidney injury, and cyclosporine's renal vasoconstriction increases the vulnerability of the kidney. The combination can lead to a greater rise in serum creatinine.
How serious is the interaction between Contrast media and Cyclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure adequate hydration, use the lowest effective dose of contrast, and monitor serum creatinine and cyclosporine levels for several days afterward. Consider holding other nephrotoxic drugs.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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