Drug interactions
Cortisone + Cyclosporin
Severity: Moderate
Cortisone and Cyclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine can raise corticosteroid exposure, and corticosteroids may in turn raise or lower cyclosporine concentrations. This may cause steroid adverse effects, seizures in rare cases, and variable cyclosporine exposure.
What this interaction means in plain words
Cortisone and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cyclosporine inhibits CYP3A4 and P-gp, reducing corticosteroid clearance, while steroids can modulate cyclosporine metabolism.
What to do
Monitor cyclosporine trough levels and clinical response, and watch for signs of corticosteroid excess. Adjust either dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Cortisone with Cyclosporin?
MediHelp rates the interaction as moderate. Cortisone and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine can raise corticosteroid exposure, and corticosteroids may in turn raise or lower cyclosporine concentrations. This may cause steroid adverse effects, seizures in rare cases, and variable cyclosporine exposure.
How serious is the interaction between Cortisone and Cyclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough levels and clinical response, and watch for signs of corticosteroid excess. Adjust either dose as needed.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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