Drug interactions
Cortisone + Empagliflozin-metformin
Severity: Moderate
Cortisone and Empagliflozin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cortisone is a systemic corticosteroid that raises blood glucose. It can offset the glucose-lowering effect of empagliflozin-metformin and lead to worse glycemic control, particularly with higher or prolonged doses.
What this interaction means in plain words
Cortisone and Empagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Glucocorticoids increase hepatic gluconeogenesis and induce peripheral insulin resistance, opposing the effects of antidiabetic drugs.
What to do
Monitor blood glucose closely during corticosteroid therapy and when it is stopped. Be prepared to raise antidiabetic doses during treatment and lower them afterwards.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-metformin
Frequently asked questions
Can I take Cortisone with Empagliflozin-metformin?
MediHelp rates the interaction as moderate. Cortisone and Empagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cortisone is a systemic corticosteroid that raises blood glucose. It can offset the glucose-lowering effect of empagliflozin-metformin and lead to worse glycemic control, particularly with higher or prolonged doses.
How serious is the interaction between Cortisone and Empagliflozin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during corticosteroid therapy and when it is stopped. Be prepared to raise antidiabetic doses during treatment and lower them afterwards.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
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