Drug interactions
Cortisone + Eprosartan-hydrochlorothiazide
Severity: Moderate
Cortisone and Eprosartan-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cortisone has some mineralocorticoid activity and promotes renal potassium loss, as does hydrochlorothiazide. Together they can lower serum potassium more than either drug alone, which may predispose to arrhythmias or muscle weakness.
What this interaction means in plain words
Cortisone and Eprosartan-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive renal potassium wasting from thiazide diuresis and corticosteroid mineralocorticoid effect.
What to do
Monitor serum potassium and magnesium periodically, especially with prolonged or high-dose steroid therapy, and supplement potassium if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Cortisone with Eprosartan-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Cortisone and Eprosartan-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cortisone has some mineralocorticoid activity and promotes renal potassium loss, as does hydrochlorothiazide. Together they can lower serum potassium more than either drug alone, which may predispose to arrhythmias or muscle weakness.
How serious is the interaction between Cortisone and Eprosartan-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium periodically, especially with prolonged or high-dose steroid therapy, and supplement potassium if needed.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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