Drug interactions
Cortisone + Flurbiprofen
Severity: Moderate
Cortisone and Flurbiprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Using an NSAID with a systemic corticosteroid increases the risk of gastric ulceration and gastrointestinal bleeding. The risk is higher in older adults and with long-term or high-dose therapy.
What this interaction means in plain words
Cortisone and Flurbiprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive GI mucosal injury: NSAIDs reduce protective prostaglandins while corticosteroids impair mucosal healing.
What to do
Use the lowest effective doses for the shortest time and consider a proton pump inhibitor in at-risk patients. Monitor for signs of GI bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Frequently asked questions
Can I take Cortisone with Flurbiprofen?
MediHelp rates the interaction as moderate. Cortisone and Flurbiprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Using an NSAID with a systemic corticosteroid increases the risk of gastric ulceration and gastrointestinal bleeding. The risk is higher in older adults and with long-term or high-dose therapy.
How serious is the interaction between Cortisone and Flurbiprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses for the shortest time and consider a proton pump inhibitor in at-risk patients. Monitor for signs of GI bleeding.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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