Drug interactions
Cortisone + Gliclazide
Severity: Moderate
Cortisone and Gliclazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic corticosteroids such as cortisone raise blood glucose and can reduce the effectiveness of gliclazide. Patients may need higher antidiabetic doses during steroid therapy, and a reduction again when it is stopped.
What this interaction means in plain words
Cortisone and Gliclazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Corticosteroids increase hepatic gluconeogenesis and induce peripheral insulin resistance, opposing the hypoglycaemic action of the sulfonylurea.
What to do
Monitor blood glucose more frequently during corticosteroid therapy and increase the antidiabetic dose as needed. Lower the dose again when the steroid is tapered to avoid hypoglycaemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cortisone and Gliclazide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Gliclazide
Frequently asked questions
Can I take Cortisone with Gliclazide?
MediHelp rates the interaction as moderate. Cortisone and Gliclazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic corticosteroids such as cortisone raise blood glucose and can reduce the effectiveness of gliclazide. Patients may need higher antidiabetic doses during steroid therapy, and a reduction again when it is stopped.
How serious is the interaction between Cortisone and Gliclazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently during corticosteroid therapy and increase the antidiabetic dose as needed. Lower the dose again when the steroid is tapered to avoid hypoglycaemia.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
