Drug interactions
Cortisone + Glipizide-metformin
Severity: Moderate
Cortisone and Glipizide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic corticosteroids such as cortisone raise blood glucose and can worsen control in patients with diabetes. The effect of glipizide and metformin may be reduced, especially with higher or prolonged steroid doses.
What this interaction means in plain words
Cortisone and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Glucocorticoids increase hepatic gluconeogenesis and induce peripheral insulin resistance, opposing the effects of antidiabetic drugs.
What to do
Monitor blood glucose more frequently during corticosteroid therapy and increase antidiabetic doses if needed. Reduce the doses again when the steroid is tapered to avoid hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Frequently asked questions
Can I take Cortisone with Glipizide-metformin?
MediHelp rates the interaction as moderate. Cortisone and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic corticosteroids such as cortisone raise blood glucose and can worsen control in patients with diabetes. The effect of glipizide and metformin may be reduced, especially with higher or prolonged steroid doses.
How serious is the interaction between Cortisone and Glipizide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently during corticosteroid therapy and increase antidiabetic doses if needed. Reduce the doses again when the steroid is tapered to avoid hypoglycemia.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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