Drug interactions
Cortisone + Glyburide-metformin
Severity: Moderate
Cortisone and Glyburide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cortisone is a glucocorticoid that raises blood glucose by increasing hepatic gluconeogenesis and insulin resistance. It can reduce the effectiveness of glyburide and metformin and cause hyperglycemia, and glucose may fall again when the steroid is stopped.
What this interaction means in plain words
Cortisone and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism through glucocorticoid-induced insulin resistance and increased hepatic glucose output.
What to do
Monitor blood glucose closely during corticosteroid therapy and increase antidiabetic doses as needed. Reduce doses again when the steroid is tapered or stopped to avoid hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Frequently asked questions
Can I take Cortisone with Glyburide-metformin?
MediHelp rates the interaction as moderate. Cortisone and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cortisone is a glucocorticoid that raises blood glucose by increasing hepatic gluconeogenesis and insulin resistance. It can reduce the effectiveness of glyburide and metformin and cause hyperglycemia, and glucose may fall again when the steroid is stopped.
How serious is the interaction between Cortisone and Glyburide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during corticosteroid therapy and increase antidiabetic doses as needed. Reduce doses again when the steroid is tapered or stopped to avoid hypoglycemia.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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