Drug interactions
Cortisone + Insulin glargine-lixisenatide
Severity: Moderate
Cortisone and Insulin glargine-lixisenatide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids raise blood glucose and increase insulin requirements, which can lead to loss of glycemic control. The effect is greater with higher doses and prolonged use.
What this interaction means in plain words
Cortisone and Insulin glargine-lixisenatide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Glucocorticoids promote hepatic gluconeogenesis and peripheral insulin resistance, antagonizing insulin.
What to do
Monitor blood glucose closely during corticosteroid therapy and increase the insulin dose as needed. Reduce it again when the steroid is tapered or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine-lixisenatide
- Albiglutide + Insulin glargine-lixisenatide Major
- Chlorpropamide + Insulin glargine-lixisenatide Major
- Dulaglutide + Insulin glargine-lixisenatide Major
- Ethanol + Insulin glargine-lixisenatide Major
- Exenatide injectable + Insulin glargine-lixisenatide Major
- Glimepiride + Insulin glargine-lixisenatide Major
Frequently asked questions
Can I take Cortisone with Insulin glargine-lixisenatide?
MediHelp rates the interaction as moderate. Cortisone and Insulin glargine-lixisenatide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids raise blood glucose and increase insulin requirements, which can lead to loss of glycemic control. The effect is greater with higher doses and prolonged use.
How serious is the interaction between Cortisone and Insulin glargine-lixisenatide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during corticosteroid therapy and increase the insulin dose as needed. Reduce it again when the steroid is tapered or stopped.
What other medicines interact with Insulin glargine-lixisenatide?
MediHelp also lists interactions of Insulin glargine-lixisenatide with, for example, Albiglutide, Chlorpropamide, Dulaglutide. The full list is on the Insulin glargine-lixisenatide page.
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