Drug interactions
Cortisone + Insulin glulisine
Severity: Moderate
Cortisone and Insulin glulisine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic corticosteroids such as cortisone raise blood glucose and can substantially increase insulin requirements. Hyperglycemia may be marked, especially post-prandially, and resolves when the steroid is withdrawn.
What this interaction means in plain words
Cortisone and Insulin glulisine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Glucocorticoids increase hepatic gluconeogenesis and cause peripheral insulin resistance, opposing insulin.
What to do
Monitor blood glucose frequently, particularly post-meal, and increase mealtime insulin as needed; reduce the dose again as the steroid is tapered.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glulisine
Frequently asked questions
Can I take Cortisone with Insulin glulisine?
MediHelp rates the interaction as moderate. Cortisone and Insulin glulisine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic corticosteroids such as cortisone raise blood glucose and can substantially increase insulin requirements. Hyperglycemia may be marked, especially post-prandially, and resolves when the steroid is withdrawn.
How serious is the interaction between Cortisone and Insulin glulisine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently, particularly post-meal, and increase mealtime insulin as needed; reduce the dose again as the steroid is tapered.
What other medicines interact with Insulin glulisine?
MediHelp also lists interactions of Insulin glulisine with, for example, Alogliptin-pioglitazone, Ethanol, Pentamidine. The full list is on the Insulin glulisine page.
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