Drug interactions
Cortisone + Measles mumps and rubella vaccine
Severity: Major
Cortisone and Measles mumps and rubella vaccine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic corticosteroids suppress immunity in a dose and duration dependent way, so the vaccine response may be poor and live viruses may cause disease. Low-dose or short courses carry little risk.
What this interaction means in plain words
Cortisone and Measles mumps and rubella vaccine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Glucocorticoid-mediated immunosuppression impairs vaccine response and control of live attenuated viruses.
What to do
Defer live vaccines while on high-dose or prolonged systemic corticosteroids and for about one month after stopping. Low-dose or short-term therapy generally does not preclude vaccination.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Measles mumps and rubella vaccine
- Adalimumab + Measles mumps and rubella vaccine Contraindicated
- Anakinra + Measles mumps and rubella vaccine Contraindicated
- Antithymocyte globulin equine + Measles mumps and rubella vaccine Contraindicated
- Antithymocyte globulin rabbit + Measles mumps and rubella vaccine Contraindicated
- Azathioprine + Measles mumps and rubella vaccine Contraindicated
- Basiliximab + Measles mumps and rubella vaccine Contraindicated
Frequently asked questions
Can I take Cortisone with Measles mumps and rubella vaccine?
MediHelp rates the interaction as major. Cortisone and Measles mumps and rubella vaccine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Systemic corticosteroids suppress immunity in a dose and duration dependent way, so the vaccine response may be poor and live viruses may cause disease. Low-dose or short courses carry little risk.
How serious is the interaction between Cortisone and Measles mumps and rubella vaccine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Defer live vaccines while on high-dose or prolonged systemic corticosteroids and for about one month after stopping. Low-dose or short-term therapy generally does not preclude vaccination.
What other medicines interact with Measles mumps and rubella vaccine?
MediHelp also lists interactions of Measles mumps and rubella vaccine with, for example, Adalimumab, Anakinra, Antithymocyte globulin equine. The full list is on the Measles mumps and rubella vaccine page.
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