Drug interactions
Cortisone + Metformin-repaglinide
Severity: Moderate
Cortisone and Metformin-repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cortisone is a glucocorticoid that raises blood glucose and may reduce the effect of metformin and repaglinide. Its weak CYP3A4 induction is unlikely to matter clinically, so the pharmacodynamic effect dominates.
What this interaction means in plain words
Cortisone and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Glucocorticoid-induced insulin resistance and increased hepatic glucose output oppose the antidiabetic drugs, with minor CYP3A4 induction.
What to do
Monitor glucose when cortisone is started, changed or stopped, and adjust the antidiabetic regimen accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Frequently asked questions
Can I take Cortisone with Metformin-repaglinide?
MediHelp rates the interaction as moderate. Cortisone and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cortisone is a glucocorticoid that raises blood glucose and may reduce the effect of metformin and repaglinide. Its weak CYP3A4 induction is unlikely to matter clinically, so the pharmacodynamic effect dominates.
How serious is the interaction between Cortisone and Metformin-repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose when cortisone is started, changed or stopped, and adjust the antidiabetic regimen accordingly.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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