Drug interactions
Cortisone + Nateglinide
Severity: Moderate
Cortisone and Nateglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic corticosteroids such as cortisone raise blood glucose and can reduce the effectiveness of antidiabetic drugs including nateglinide. Hyperglycemia may be noticeable with prolonged or higher-dose use.
What this interaction means in plain words
Cortisone and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism through increased hepatic gluconeogenesis and peripheral insulin resistance.
What to do
Monitor blood glucose closely during corticosteroid therapy and increase antidiabetic treatment if needed; reduce it again when the steroid is withdrawn to avoid hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Frequently asked questions
Can I take Cortisone with Nateglinide?
MediHelp rates the interaction as moderate. Cortisone and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic corticosteroids such as cortisone raise blood glucose and can reduce the effectiveness of antidiabetic drugs including nateglinide. Hyperglycemia may be noticeable with prolonged or higher-dose use.
How serious is the interaction between Cortisone and Nateglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during corticosteroid therapy and increase antidiabetic treatment if needed; reduce it again when the steroid is withdrawn to avoid hypoglycemia.
What other medicines interact with Nateglinide?
MediHelp also lists interactions of Nateglinide with, for example, Albiglutide, Alogliptin-metformin, Alogliptin-pioglitazone. The full list is on the Nateglinide page.
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