Drug interactions
Cortisone + Nilotinib
Severity: Minor
Cortisone and Nilotinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib may raise corticosteroid exposure through CYP3A4 inhibition, while systemic corticosteroids can weakly induce CYP3A4 and slightly reduce nilotinib levels. Clinical effects are expected to be modest.
What this interaction means in plain words
Cortisone and Nilotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing CYP3A4 effects: inhibition by nilotinib and weak induction by corticosteroids.
What to do
No dose change is needed routinely. Monitor for corticosteroid excess and for nilotinib response during prolonged high-dose therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Cortisone with Nilotinib?
MediHelp rates the interaction as minor. Cortisone and Nilotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nilotinib may raise corticosteroid exposure through CYP3A4 inhibition, while systemic corticosteroids can weakly induce CYP3A4 and slightly reduce nilotinib levels. Clinical effects are expected to be modest.
How serious is the interaction between Cortisone and Nilotinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed routinely. Monitor for corticosteroid excess and for nilotinib response during prolonged high-dose therapy.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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