Drug interactions
Cortisone + Ofloxacin
Severity: Moderate
Cortisone and Ofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic corticosteroids increase the risk of fluoroquinolone-associated tendinitis and tendon rupture. The risk is highest in older patients, in transplant recipients and with prolonged steroid use.
What this interaction means in plain words
Cortisone and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive tendon toxicity from fluoroquinolone effects on tendon tissue and corticosteroid-mediated collagen impairment.
What to do
Prefer a non-quinolone antibiotic when feasible, particularly in patients over 60. If used together, instruct the patient to stop ofloxacin and seek care at the first sign of tendon pain.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Frequently asked questions
Can I take Cortisone with Ofloxacin?
MediHelp rates the interaction as moderate. Cortisone and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic corticosteroids increase the risk of fluoroquinolone-associated tendinitis and tendon rupture. The risk is highest in older patients, in transplant recipients and with prolonged steroid use.
How serious is the interaction between Cortisone and Ofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-quinolone antibiotic when feasible, particularly in patients over 60. If used together, instruct the patient to stop ofloxacin and seek care at the first sign of tendon pain.
What other medicines interact with Ofloxacin?
MediHelp also lists interactions of Ofloxacin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Ofloxacin page.
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