Drug interactions
Cortisone + Repaglinide
Severity: Moderate
Cortisone and Repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cortisone raises blood glucose through its glucocorticoid action, which opposes repaglinide. Any enzyme induction by corticosteroids is a minor additional contributor.
What this interaction means in plain words
Cortisone and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Glucocorticoid-induced insulin resistance and hepatic gluconeogenesis oppose repaglinide; weak CYP3A4 induction may lower its levels.
What to do
Monitor blood glucose when cortisone is started, changed or stopped. Increase the repaglinide dose as needed, and reduce it again when the steroid is withdrawn.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporin + Repaglinide Major
- Deferasirox + Repaglinide Major
Frequently asked questions
Can I take Cortisone with Repaglinide?
MediHelp rates the interaction as moderate. Cortisone and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cortisone raises blood glucose through its glucocorticoid action, which opposes repaglinide. Any enzyme induction by corticosteroids is a minor additional contributor.
How serious is the interaction between Cortisone and Repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when cortisone is started, changed or stopped. Increase the repaglinide dose as needed, and reduce it again when the steroid is withdrawn.
What other medicines interact with Repaglinide?
MediHelp also lists interactions of Repaglinide with, for example, Gemfibrozil, Clarithromycin, Clopidogrel. The full list is on the Repaglinide page.
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