Drug interactions
Cortisone + Rocuronium
Severity: Moderate
Cortisone and Rocuronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids given with nondepolarizing neuromuscular blockers have been associated with acute myopathy, particularly in critically ill patients receiving prolonged blockade. This may cause persistent weakness and delay ventilator weaning.
What this interaction means in plain words
Cortisone and Rocuronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Probable additive myotoxicity; the exact mechanism is not fully established.
What to do
Limit the duration and dose of neuromuscular blockade where possible. Monitor for persistent weakness and creatine kinase during prolonged coadministration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rocuronium
Frequently asked questions
Can I take Cortisone with Rocuronium?
MediHelp rates the interaction as moderate. Cortisone and Rocuronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids given with nondepolarizing neuromuscular blockers have been associated with acute myopathy, particularly in critically ill patients receiving prolonged blockade. This may cause persistent weakness and delay ventilator weaning.
How serious is the interaction between Cortisone and Rocuronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit the duration and dose of neuromuscular blockade where possible. Monitor for persistent weakness and creatine kinase during prolonged coadministration.
What other medicines interact with Rocuronium?
MediHelp also lists interactions of Rocuronium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Rocuronium page.
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