Drug interactions
Cortisone + Sunitinib
Severity: Minor
Cortisone and Sunitinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids may weakly induce CYP3A4, which could modestly lower sunitinib concentrations. The effect is probably small at replacement doses of cortisone.
What this interaction means in plain words
Cortisone and Sunitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible weak CYP3A4 induction by cortisone increasing sunitinib metabolism.
What to do
No routine adjustment is needed. Watch for reduced clinical response if high-dose or prolonged corticosteroid therapy is used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Frequently asked questions
Can I take Cortisone with Sunitinib?
MediHelp rates the interaction as minor. Cortisone and Sunitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Corticosteroids may weakly induce CYP3A4, which could modestly lower sunitinib concentrations. The effect is probably small at replacement doses of cortisone.
How serious is the interaction between Cortisone and Sunitinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Watch for reduced clinical response if high-dose or prolonged corticosteroid therapy is used.
What other medicines interact with Sunitinib?
MediHelp also lists interactions of Sunitinib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sunitinib page.
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