Drug interactions
Creatine + Cyclosporin
Severity: Minor
Creatine and Cyclosporin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Creatine supplements may theoretically add to cyclosporine renal stress and can raise serum creatinine, confounding assessment of kidney function. Evidence of actual harm is limited to case reports with other nephrotoxins.
What this interaction means in plain words
Creatine and Cyclosporin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical additive renal effects; creatine also raises serum creatinine independently.
What to do
Advise against creatine supplementation in patients on cyclosporine, or monitor renal function with cystatin C if it is used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Creatine with Cyclosporin?
MediHelp rates the interaction as minor. Creatine and Cyclosporin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Creatine supplements may theoretically add to cyclosporine renal stress and can raise serum creatinine, confounding assessment of kidney function. Evidence of actual harm is limited to case reports with other nephrotoxins.
How serious is the interaction between Creatine and Cyclosporin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise against creatine supplementation in patients on cyclosporine, or monitor renal function with cystatin C if it is used.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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