Drug interactions
Creatine + Lisinopril
Severity: Minor
Creatine and Lisinopril: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Creatine supplementation has been associated with isolated reports of renal impairment and raises serum creatinine without true injury. With lisinopril, which also affects renal hemodynamics, there is a theoretical additive renal risk and interpretation of creatinine may be confounded.
What this interaction means in plain words
Creatine and Lisinopril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical additive renal effects; creatine also increases serum creatinine independently of filtration.
What to do
Monitor renal function and interpret creatinine cautiously in patients taking creatine, and consider cystatin C if clarification is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lisinopril
- Aliskiren + Lisinopril Contraindicated
- Lisinopril + Protein a column Contraindicated
- Lisinopril + Sacubitril / valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Lisinopril Major
- Amiloride + Lisinopril Major
Frequently asked questions
Can I take Creatine with Lisinopril?
MediHelp rates the interaction as minor. Creatine and Lisinopril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Creatine supplementation has been associated with isolated reports of renal impairment and raises serum creatinine without true injury. With lisinopril, which also affects renal hemodynamics, there is a theoretical additive renal risk and interpretation of creatinine may be confounded.
How serious is the interaction between Creatine and Lisinopril?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and interpret creatinine cautiously in patients taking creatine, and consider cystatin C if clarification is needed.
What other medicines interact with Lisinopril?
MediHelp also lists interactions of Lisinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Lisinopril page.
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