Drug interactions
Creatine + Ramipril
Severity: Minor
Creatine and Ramipril: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Creatine supplementation can raise serum creatinine and has been theorized to stress the kidneys, while ACE inhibitors reduce glomerular filtration pressure. Together they may make renal function monitoring harder to interpret and might add to renal risk in vulnerable patients. Clinical evidence of harm is limited.
What this interaction means in plain words
Creatine and Ramipril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical additive renal effects; creatine also raises creatinine independent of true GFR change.
What to do
Check serum creatinine and potassium at baseline and periodically in patients taking both, interpreting creatinine rises with the supplement in mind. Avoid creatine in patients with pre-existing renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ramipril
- Aliskiren + Ramipril Contraindicated
- Protein a column + Ramipril Contraindicated
- Ramipril + Sacubitril / valsartan Contraindicated
- Ramipril + Sacubitril-valsartan Contraindicated
- Amifostine + Ramipril Major
- Amiloride + Ramipril Major
Frequently asked questions
Can I take Creatine with Ramipril?
MediHelp rates the interaction as minor. Creatine and Ramipril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Creatine supplementation can raise serum creatinine and has been theorized to stress the kidneys, while ACE inhibitors reduce glomerular filtration pressure. Together they may make renal function monitoring harder to interpret and might add to renal risk in vulnerable patients. Clinical evidence of harm is limited.
How serious is the interaction between Creatine and Ramipril?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum creatinine and potassium at baseline and periodically in patients taking both, interpreting creatinine rises with the supplement in mind. Avoid creatine in patients with pre-existing renal impairment.
What other medicines interact with Ramipril?
MediHelp also lists interactions of Ramipril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Ramipril page.
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