Drug interactions
Cyanocobalamin + Ibuprofen / famotidine
Severity: Minor
Cyanocobalamin and Ibuprofen / famotidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Famotidine, an H2-receptor antagonist, reduces gastric acid and may with prolonged use lower absorption of food-bound vitamin B12. The effect is usually small and relevant mainly in long-term users or those with marginal B12 intake.
What this interaction means in plain words
Cyanocobalamin and Ibuprofen / famotidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Reduced gastric acid secretion impairs release of protein-bound B12 for absorption.
What to do
Monitor B12 status periodically in patients on long-term therapy, especially older adults or those with other risk factors, and supplement if deficient.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyanocobalamin
Frequently asked questions
Can I take Cyanocobalamin with Ibuprofen / famotidine?
MediHelp rates the interaction as minor. Cyanocobalamin and Ibuprofen / famotidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Famotidine, an H2-receptor antagonist, reduces gastric acid and may with prolonged use lower absorption of food-bound vitamin B12. The effect is usually small and relevant mainly in long-term users or those with marginal B12 intake.
How serious is the interaction between Cyanocobalamin and Ibuprofen / famotidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor B12 status periodically in patients on long-term therapy, especially older adults or those with other risk factors, and supplement if deficient.
What other medicines interact with Cyanocobalamin?
MediHelp also lists interactions of Cyanocobalamin with, for example, Chloramphenicol, Dichlorphenamide, Metformin. The full list is on the Cyanocobalamin page.
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