Drug interactions
Cyanocobalamin + Lansoprazole
Severity: Minor
Cyanocobalamin and Lansoprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Long-term acid suppression reduces gastric release of food-bound vitamin B12 and can contribute to deficiency. Crystalline cyanocobalamin supplements are less dependent on acid, so the effect is smaller with supplements than with dietary B12.
What this interaction means in plain words
Cyanocobalamin and Lansoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cyanocobalamin belongs to Miscellaneous; Lansoprazole belongs to Gastrointestinal Tract.
Why it happens
Reduced gastric acid impairs release of protein-bound B12 and may limit absorption.
What to do
Check B12 status periodically in patients on prolonged PPI therapy, especially older adults or those with other risk factors, and supplement if low.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Other interactions of Cyanocobalamin
Frequently asked questions
Can I take Cyanocobalamin with Lansoprazole?
MediHelp rates the interaction as minor. Cyanocobalamin and Lansoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Long-term acid suppression reduces gastric release of food-bound vitamin B12 and can contribute to deficiency. Crystalline cyanocobalamin supplements are less dependent on acid, so the effect is smaller with supplements than with dietary B12.
How serious is the interaction between Cyanocobalamin and Lansoprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check B12 status periodically in patients on prolonged PPI therapy, especially older adults or those with other risk factors, and supplement if low.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
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