Drug interactions
Cyanocobalamin + Metformin-sitagliptin
Severity: Minor
Cyanocobalamin and Metformin-sitagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Long-term metformin use is associated with lower serum vitamin B12 levels and occasionally deficiency, which can lead to anemia or neuropathy. Cyanocobalamin supplementation corrects this rather than causing harm.
What this interaction means in plain words
Cyanocobalamin and Metformin-sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cyanocobalamin belongs to Miscellaneous; Metformin-sitagliptin belongs to Endocrine.
Why it happens
Metformin is thought to impair calcium-dependent ileal absorption of the vitamin B12-intrinsic factor complex.
What to do
Measure vitamin B12 periodically in patients on long-term metformin, especially with anemia or neuropathy, and supplement if low.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cyanocobalamin and Metformin-sitagliptin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Metformin-sitagliptin
Other interactions of Cyanocobalamin
Frequently asked questions
Can I take Cyanocobalamin with Metformin-sitagliptin?
MediHelp rates the interaction as minor. Cyanocobalamin and Metformin-sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Long-term metformin use is associated with lower serum vitamin B12 levels and occasionally deficiency, which can lead to anemia or neuropathy. Cyanocobalamin supplementation corrects this rather than causing harm.
How serious is the interaction between Cyanocobalamin and Metformin-sitagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Measure vitamin B12 periodically in patients on long-term metformin, especially with anemia or neuropathy, and supplement if low.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
