Drug interactions
Cyanocobalamin + Octreotide
Severity: Minor
Cyanocobalamin and Octreotide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Octreotide can reduce intestinal absorption of nutrients, including vitamin B12, and long-term use has been linked to lower B12 levels. This is relevant mainly to oral cyanocobalamin and to long-term octreotide therapy.
What this interaction means in plain words
Cyanocobalamin and Octreotide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cyanocobalamin belongs to Miscellaneous; Octreotide belongs to Endocrine.
Why it happens
Octreotide suppresses gastrointestinal secretions and motility, reducing absorption of vitamin B12.
What to do
Monitor vitamin B12 status during long-term octreotide therapy. Use parenteral cyanocobalamin if deficiency develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cyanocobalamin and Octreotide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Octreotide
Other interactions of Cyanocobalamin
Frequently asked questions
Can I take Cyanocobalamin with Octreotide?
MediHelp rates the interaction as minor. Cyanocobalamin and Octreotide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Octreotide can reduce intestinal absorption of nutrients, including vitamin B12, and long-term use has been linked to lower B12 levels. This is relevant mainly to oral cyanocobalamin and to long-term octreotide therapy.
How serious is the interaction between Cyanocobalamin and Octreotide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor vitamin B12 status during long-term octreotide therapy. Use parenteral cyanocobalamin if deficiency develops.
What other medicines interact with Octreotide?
MediHelp also lists interactions of Octreotide with, for example, Adagrasib, Amisulpride, Arsenic trioxide. The full list is on the Octreotide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
