Drug interactions
Cyclobenzaprine + Deferasirox
Severity: Moderate
Cyclobenzaprine and Deferasirox: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox inhibits CYP1A2, a major pathway for cyclobenzaprine clearance, so cyclobenzaprine exposure may rise. This can increase sedation, anticholinergic effects and other dose-related adverse effects.
What this interaction means in plain words
Cyclobenzaprine and Deferasirox can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclobenzaprine belongs to Musculoskeletal; Deferasirox belongs to Miscellaneous.
Why it happens
Deferasirox inhibits CYP1A2-mediated metabolism of cyclobenzaprine, raising its plasma concentrations.
What to do
Monitor for excess sedation, dry mouth, tachycardia and confusion, and consider a lower cyclobenzaprine dose or an alternative muscle relaxant if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Other interactions of Deferasirox
Frequently asked questions
Can I take Cyclobenzaprine with Deferasirox?
MediHelp rates the interaction as moderate. Cyclobenzaprine and Deferasirox can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferasirox inhibits CYP1A2, a major pathway for cyclobenzaprine clearance, so cyclobenzaprine exposure may rise. This can increase sedation, anticholinergic effects and other dose-related adverse effects.
How serious is the interaction between Cyclobenzaprine and Deferasirox?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation, dry mouth, tachycardia and confusion, and consider a lower cyclobenzaprine dose or an alternative muscle relaxant if symptoms develop.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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